Study of the association of toll like-4 receptor gene polymorphism (rs1927911) and susceptibility to urinary tract infection among Iraqi patients

Introduction and Aim: Toll-like receptors (TLRs) are cell innate immune that explore microbial molecules. A quantity of single-nucleotide polymorphisms (SNPs) within the TLR genes have been related with altered susceptibility to infectious, inflammatory, allergic diseases suggesting: This study was conducted investigate relationship between genetic polymorphism in TLR4 gene (rs1927911) UTIs a sample Iraqi patients. Materials Methods: Blood samples were collected from 220 patients who had 69 healthy subjects as control group, during period October 2021 March 2022, at Rheumatology Department Clinic Consultant Al-Yarmouk Hospital. The included an extraction genomic DNA PCR technique, detect role variation site risk factor for incidence UTIs. Results: results genotype distribution allele frequency rs1927911 indicated, CC (18.6 %), CT (70 %) TT (11.4 among while 57.9 % 26.1%; 16% CT, genotypes respectively control. Heterozygous (CT) may be considered revealed significant differences controls serum levels TLR4, IL-6 IL-2, TNF-alpha IL-10 P 0.005. In addition, data found highly difference level protein carrier genotype. Conclusion: our findings indicated carriers significantly more prone